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Cialis Soft is an advanced formula of branded Cialis, a leader in the fight against impotence.

Mechanism of action

Due to the rapid entry into the bloodstream, bypassing the digestive system, Cialis Soft has an almost instant effect. The effect is manifested after 20-25 minutes.

The drug blocks phosphodiesterase and promotes the release of nitric oxide, which normalizes blood circulation in the body and promotes its flow to the genitals. The drug causes a persistent and prolonged natural erection and gives the man the ability to have full sex.

But do not worry about the fact that an erection will accompany you throughout the duration of the drug, occurring in the most inappropriate conditions. It will occur only as a result of sexual stimulation. As soon as sexual intercourse is finished, the penis becomes relaxed.

Cialis Soft has a prolonged action. The effect lasts for 36 hours, which is a record among drugs used to increase potency.

Indications

  • Erectile dysfunction;
  • Symptoms of the lower urinary tract in men with BPH (benign prostatic hyperplasia);
  • Erectile dysfunction in men with lower urinary tract symptoms with BPH.

Benefits

  • Contains the active ingredient tadalafil in an amount of 20 mg;
  • The effect of the drug occurs within 10-20 minutes (faster than ordinary Cialis);
  • Long-lasting effect (approximately 36 hours);
  • An erection is restored in a short period of time after ejaculation;
  • The sensitivity of the male genital increases;
  • Can be combined with alcoholic beverages and fatty dishes;
  • Effective in almost 100% of cases.

Dosage

The drug is taken orally. Just place in under the tongue and wait until it dissolves.

Treatment of erectile dysfunction:

  • Patients who lead an active sex life (more than 2 times a week) are recommended to take 5 mg once a day daily, regardless of meals. The time of administration should be the same every day. If the patient has individual sensitivity to the drug, the dose should be reduced to 2.5 mg.
  • If the patient’s sex life is not frequent (at least 2 times a week), then he it recommended to take 20 mg per day shortly before sexual activity.
    The daily dose of Cialis Soft should not exceed 20 mg.

Treatment of benign prostatic hyperplasia or erectile dysfunction / benign prostatic hyperplasia:

  • Patients with these diagnoses are recommended to take 5 mg once a day. The drug must be taken at the same time, regardless of sexual activity. The duration of treatment is determined individually by the doctor.

Dose adjustment:

  • Patients with mild renal failure (CC from 51 to 80 ml / min): dose adjustment is not needed;
  • Patients with moderate renal failure (CC from 31 to 50 ml / min): dose adjustment is not needed;
  • Patients with severe renal failure (CC less than 30 / min and on hemodialysis): taking the drug more than 1 time per day is contraindicated.

Overdose

When the drug was taken at a dosage of up to 500 mg by healthy men (once) and men with erectile dysfunction up to 100 mg per day (repeatedly), side effects were manifested in the same way as when using the drug in low dosages.

Treatment: symptomatic standard treatment is necessary. Tadalafil is practically not excreted during hemodialysis.

Side effects

  • Rare side effects: swelling of the eyelids, impaired vision, injection of vessels of the sclera of the eyeball, non-arterial anterior ischemic optic neuropathy, occlusion of the vessels of the retina, sudden hearing loss, myocardial infarction, ventricular arrhythmias, unstable angina, nosebleeds, urticaria, Stevens-Johnson syndrome, exfoliative dermatitis, prolonged erection, priapism, facial edema, sudden cardiac death, stroke, fainting, early ischemic attacks, migraine, epileptic seizure, transient amnesia;
  • Uncommon side effects: hypersensitivity reactions, blurred visual perception, pain in the eyeball, palpitations, tachycardia, decreased blood pressure (in patients who have already taken antihypertensive drugs), increased blood pressure, nasal congestion, shortness of breath, abdominal pain, gastroesophageal reflux , rash, hyperhidrosis (excessive sweating), chest pain;
  • Common side effects: dizziness, dyspepsia, back pain, myalgia, headache.

Contraindications

  • Use with drugs that contain any nitrates;
  • Age under 18 years;
  • Cardiovascular diseases: myocardial infarction during the last three months (90 days), the occurrence of an attack of angina pectoris during sexual intercourse, unstable angina pectoris, uncontrolled arrhythmia, chronic heart failure (grades 2-4 according to NYHA classification), ischemic stroke in the last 6 months, arterial hypotension (blood pressure less than 90/50 mm Hg), uncontrolled arterial hypertension;
  • Use with medications that are intended to treat erectile dysfunction, as well as doxazosin;
  • Loss of vision due to non-arterial anterior ischemic neuropathy of the optic nerve;
  • Lactose intolerance, lactase deficiency, gluco-galactose malabsorption;
  • Frequent intake (more than 2 times a week) in patients with chronic renal failure (CC less than 30 ml / min);
  • Individual hypersensitivity to the components of the drug.

With caution:

  • Severe renal failure (since there is no data on the use of Cialis Soft in this category of people);
  • Use of alpha1-blockers (simultaneous administration may lead to symptomatic arterial hypotension);
  • Predisposition to priapism (leukemia, multiple myeloma, sickle cell anemia);
  • Anatomical deformation of the genital organ (Peyronie’s disease, angular curvature, cavernous fibrosis);
  • Together with powerful inhibitors of the isoenzyme CYP3A4 (saquinavir, ritonavir, itraconazole, erythromycin, ketoconazole);
  • Use of antihypertensive drugs.

Compatibility with other drugs

  • Other HIV protease inhibitors and CYP3A4 isoenzyme inhibitors (erythromycin, itraconazole, etc.) may increase tadalafil activity but such a specific interaction has not been studied;
  • Selective inducers of the CYP3A4 isoenzyme (for example, rifampicin 600 g / day) will reduce the concentration of tadalafil in plasma;
  • Antacid (magnesium hydroxide / aluminum hydroxide) may reduce the absorption rate of tadalafil;
  • When taking tadalafil with blockers of histamine H2 receptors of nizatidine, no effect on the pharmacokinetics of the drug was found;
  • Since tadalafil has pronounced vasodilating properties, it can enhance the effect of antihypertensive drugs, which are aimed at lowering blood pressure;
  • Alcohol does not change the effect of tadalafil.

Other combinations have not been studied, and therefore taking the drug with other medicines is contraindicated.