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Generic Lasix is a pharmacological agent that specifically acts on the kidneys, accelerating the excretion of urine from the body. It is done by inhibiting the reverse absorption of electrolytes in the tubules and the release of an appropriate amount of fluid. It is used for cardiovascular pathologies, most often for arterial hypertension for unloading the blood flow.

Indications for use

  • Edema of various origins associated with diseases of the cardiovascular system, kidneys, pregnancy, intoxication.
  • Edema of the brain and spinal cord, intracranial hypertension, pulmonary edema as emergency treatment methods.
  • High blood pressure.
  • Lack of kidney function.

Dosage and administration

Lasix tablets are used orally (on an empty stomach or with food). The prescribed dose is used once a day or every other day. The recommended single dose is 40 mg. In severe conditions, a gradual increase in dose to 600 mg per day is possible. The maximum dose is 1500 mg/day.

Overdose

Symptoms: hypovolemia, hemoconcentration, dehydration, cardiac arrhythmias (AV block, ventricular fibrillation), severe arterial hypotension, shock, orthostatic collapse, acute renal failure, delirious states, thrombosis, delirium, apathy, peripheral paralysis, confusion.

Treatment should be discontinued. If necessary, introduce a solution of electrolytes. In order to reduce the systemic absorption of the active substance, gastric lavage and sorbents are recommended.

Mechanism of action

Lasix belongs to the group of diuretic drugs. Diuretics are drugs that increase urine excretion from the body. It reduces its content in cavities, vessels, and tissues. The mechanism of action is associated with exposure to the renal apparatus, in which the reverse absorption of sodium ions is inhibited.

This contributes to faster water absorption, so it freely passes through the renal tubules and is excreted in the urine. The filtration processes in the kidneys are enhanced.

Potassium-sparing diuretics preserve potassium levels. Osmodiuretics are the only drugs that do not result in blocking urination. They are filtered, the osmotic pressure rises. Due to this, there is no reverse absorption of water, and it freely leaves the body. Very often a reduced concentration of potassium levels develops since these medicines do not have a potassium-sparing property.

Side effects

  • Allergic reactions: allergy symptoms (chills, chest pain, trembling, urticaria, skin rash), anaphylaxis (shortness of breath, hypotension, cardiac arrest), dermatitis, exacerbation/activation of systemic lupus erythematosus.
  • Metabolic disorders: hyponatremia, hypochloraemia, hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis, Bartter pseudo-syndrome, increased thirst, confusion, tetany, cramps, muscle weakness, hypovolemia.
  • Hematological disorders: aplastic anemia, agranulocytosis, thrombocytopenia, hemolytic anemia, eosinophilia, leukopenia, blood concentration.
  • Neurological disorders: paresthesia, delirium, hepatic encephalopathy.
  • Otolaryngological disorders: noise, tinnitus, hearing impairment, deafness.
  • Cardiovascular disorders: arterial hypotension (dizziness, headache, a sensation of rotation, drowsiness, weakness, blurred vision, dry mouth), orthostatic hypotension, collapse, a tendency to thrombosis, vasculitis.
  • Digestive disorders: acute pancreatitis, nausea, diarrhea, increased levels of hepatic transaminases, intrahepatic cholestasis.
  • Dermatological disorders: pruritus, rash, bullous dermatitis, urticaria, erythema multiforme, Stevens-Johnson syndrome, pemphigoid, toxic epidermal necrolysis, purpura, exfoliative dermatitis, photosensitivity, AGEP syndrome, DRESS-syndrome.
  • Urinary disorders: increased urine volume, urinary retention, tubulointerstitial nephritis, renal failure, nephrolithiasis, nephrocalcinosis.
  • Musculoskeletal disorders: rhabdomyolysis.
  • Others: increased risk of the patent ductus arteriosus when used in premature babies in the first weeks of their life.

Contraindications

  • Hypersensitivity to the active substance or to excipients;
  • Patients with an allergy to sulfonamides (sulfonamide antimicrobials or sulfonylureas);
  • Renal failure with anuria;
  • Hepatic coma and precoma;
  • Severe hypokalemia;
  • Severe hyponatremia;
  • Hypovolemia (with or without arterial hypotension) or dehydration;
  • Pronounced violations of urine outflow of any etiology (including unilateral damage to the urinary tract);
  • Digital intoxication;
  • Acute glomerulonephritis;
  • Decompensated aortic and mitral stenosis, hypertrophic obstructive cardiomyopathy;
  • Increase in central venous pressure;
  • Hyperuricemia;
  • Children’s age up to 3 years (solid dosage form);
  • Pregnancy;
  • Lactation.